15 Best Wrinkle Serums Of All Time

Your skin will thank you.

Best Wrinkle Serums getty

Aging is a natural part of life — and the alternative is, of course, not aging, so we'll take it! But our body does have its share of growing pains, and that includes fine lines and wrinkles. 

There's no magic cream that will give you total control over how to get rid of wrinkles, but finding the best wrinkle serum can diminish them and slow down their progress. There are also all sorts of things we can do with our serums — using them on their own, adding them to moisturizers and night creams, using BB or CC creams, or even combining them with our masks or as a spot treatment. 


Like with all skincare, there are all different types of products with all types of ingredients, so you are going to want to do your research. In the meantime, these wrinkle serums are a great place to start.

RELATED: 15 Best Skincare Lines For Sensitive Skin

1. W!nk Serum


The perfect skin hydrator, this CBD infused, colorless, replenishing elixir of pure botanical oils provides vital nutrients. It includes hyaluronic acid and vitamin E to enhance the skin's daytime and nighttime recovery.

(Wink-wink, $48)

2. Golden Door Moisture Rich Serum

This emollient- and antioxidant-rich serum protects, repairs, and improves the overall tone and appearance of normal-to-dry, dry, and dehydrated skin. Essential nutrients are delivered deep into the dermis, dramatically improving texture, smoothness, elasticity and firmness after only 4 weeks when used twice daily.



3. CannaSmack Peptide Serum

CannaSmack’s proprietary peptide blend helps promote collagen synthesis, firms and tones skin, and reduces and prevents the appearance of wrinkles and fine lines, all while protecting your skin from harmful photo-damage from UV rays. It’s also Leaping Bunny Cruelty Free Certified and vegan, and free from parabens, sulfates and gluten.


(CannaSmack, $70)

4. SkinMedica TNS Essential Serum

This wrinkle serum features two active formulas that combine to smooth wrinkles and regenerate skin cells for a more youthful appearance. The TNS complex is a protein- and amino acid-rich serum to reduce inflammation and the signs of aging. The APS corrective complex is a mixture of anti-aging ingredients, peptides and antioxidants to strengthen sagging skin.


(Dermstore, $281)

5. iS Clinical Active Serum

It provides anti-aging, anti-acne and brightening benefits. Clinically-proven to provide both instant and long-term results, this face serum smooths away fine lines and wrinkles while softening the skin's texture. It reduces the appearance of hyperpigmentation, redness and acne, leading to a clearer and healthier-looking complexion.


(Dermstore, $135)

6. Georgette Klinger Line Solution Complex

This innovative age-defying formula diminishes the appearance of fine lines and wrinkles while restoring firmness, bounciness and the structural integrity of your skin. It's a complex serum of rich yet balanced hydration.

(Georgette Klinger, $54)


7. DERMA E Anti-Aging Regenerative Serum

Visibly refine your skin and diminish the signs of aging with this concentrated rejuvenation treatment. Vitamin A encourages cellular renewal, reducing the look of fine lines and wrinkles for a fresher, healthier looking appearance. Vitamin E is an antioxidant and intense moisturizer, helping keep skin soft, smooth and hydrated.

(DermaE, $21.95)


8. Vitabrid Dual Serum

With two innovative ingredient technologies, Vitabrid’s Dual Serum is easily absorbed with hybridized Vitamin C (Vitabrid®) and Peptides (Peptibrid™) that deliver proven anti-aging benefits. The deep penetration of the active ingredients stimulates cells to boost collagen synthesis from deep within so that these collagen pillars will have a smoothing effect on wrinkles from the inside out.

(Barneys, $75)


9. Osmosis Renew Vitamin A Serum

This serum improves fine lines, skin texture, and thickness, inspiring and restoring the skin to boost collagen and reverse aging. It contains the most potent combination of fibroblast stimulators, which encourage the reversal of skin aging.


RELATED: 21 Best Retinol Serums To Maintain Your Youthful Glow


10. Elina Organics Ambra Lift

It is a Bio-Energized Skin Elixir which contains extracts of Baltic Amber, Marine and Silk Peptides, Hyaluronic Acid and other effective skin nutrients. It visibly lifts, energizes, tones, and firms your skin. It is scientifically proven to produce anti-aging, anti-wrinkle, anti-inflammatory and anti-oxidant effects after two applications.


(Elina Organics Skincare, $80)

11. Wrinkles Schminkles Morning After Glow Serum Face, Neck & Décolletage

This is a powerful blend of wrinkle-fighting anti-oxidants and essential fatty acids, designed to plump wrinkles and treat fine lines on your face, neck and decolletage. By using the Morning After Glow Face & Decolletage Serum during the day, you are effectively treating your skin 24 hours a day with custom designed skincare for these delicate parts of the body.


(Wrinkles Shminkles, $30)

12. InstaNatural Retinol Serum

InstaNatural’s Retinol Serum contains a carefully formulated blend of ingredients to address the most common concerns of aging. Retinol supports the skin's natural exfoliation process to soften the appearance of lines, wrinkles and discoloration, while Vitamin C, Hyaluronic Acid and Niacinamide defend and nourish to add radiance, hydration and a firm appearance to the skin.



13. Luzern Serum Absolut WE3


Serum Absolut WE3 is a triple-action serum that targets the depth, length, and width of lines. Skin looks smoother and younger thanks to high-performance stem cells, peptides, vitamins and hydrators that strengthen the most vulnerable areas. The serum also minimizes muscle contractions to keep new lines at bay.

(Luzern Labs, $150)

14. NEOVA DNA Total Repair

Groundbreaking formula with award-winning DNA repair enzymes addresses the assaults of environmental and UV stressors that damage skin, its DNA and result in the visible signs of photoaging. DNA Total Repair dramatically reduces those signs in a way no other serum can, including a 56 percent decrease in lines, size and intensity after 4 weeks when used twice daily.


(Neova, $89)

15. PRAI 24K Rose Gold Wrinkle Repair Night Serum

This remarkable overnight recovery serum is specially formulated to significantly reduce the visible signs of aging while you sleep. Key ingredients work overnight, when skin is most receptive to repair, to fill and smooth lines and wrinkles while deeply hydrating skin so you wake with a younger, smoother and healthier looking complexion.


(Prai Beauty, $19.95)

RELATED: Sleeping In This Position Makes You Get Wrinkles Faster, Says Science

Aly Walansky is a NY-based lifestyles writer. Her work appears in dozens of digital and print publications regularly. Visit her on Twitter or email her at alywalansky@gmail.com.

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