Narcissists often feel humiliated in therapy, unless the therapist does "Oh, poor baby" therapy or tells them how wonderful they are, neither of which is helpful. Treating narcissism involves lowering the patient's grandiose ideas of themselves to the reality of the person as someone working to have a satisfying life, instead of being king or queen of the universe, and raising the patient's idea of themselves as a humiliated, insignificant nothing to the reality of, again, someone working to have a satisfying life.
Everyone struggles with narcissism, and I don't just mean the characters in "Enlightened." It's a question of degree. Can good therapy make narcissism go away? I wish! It's a matter of learning to catch ourselves and think our way back to reality, rather than indulging it. When Amy is insisting that the article detailing the corruption at her company run on the front page, she's indulging her narcissism. When we run down someone else to make ourselves feel superior, we're indulging our narcissism. And whenever we indulge our narcissism, it becomes an even larger problem. If narcissism—protecting your superior position or feeling humiliated—is keeping you from fully enjoying your life, as is the case with the characters from "Enlightened," good therapy can be very helpful.