4. Adam Sandler and Drew Barrymore (The Wedding Singer '98, 50 First Dates '04) - We just adored this too-cute-for-words pair in The Wedding Singer. Their chemistry was giggle-inducing, since Drew and Adam have the just the right amount of charm for rom-com roles. When they teamed up again for 50 First Dates, we were ecstatic. However, their signature fall-in-love-with-your-unavailable/engaged-friend flick was our absolute favorite. And pretty hilarious to boot.