From the LA Times:
Although the vaccine, called Gardasil, blocked about 100% of infections by the two human papilloma virus strains it targets, it reduced the incidence of cancer precursors by only 17% overall.
[W]hen Koutsky and her colleagues considered lesions caused by all strains of the virus, the vaccine reduced the risk by only 17%.
Because researchers had previously believed that 50% of all serious precancerous lesions were caused by types 16 and 18, this rate of protection seemed inexplicably low.
Dr. George F. Sawaya and Dr. Karen Smith-McCune of UC San Francisco called the benefits of the highly touted vaccine “modest,†and said that young women and their parents should take “a cautious approach†to vaccination because of the many unanswered questions about its efficacy.
“The effect is fairly small,†Sawaya said in a telephone interview. “The recommendation for widespread vaccination of women after they become sexually active may need to be rethought.â€
Sawaya suggested in the editorial he co-wrote that the small size of the protection could be because other strains of HPV are filling the gap when types 16 and 18 are eliminated.


